PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers アイソフォーム特異的製品
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PROTAC Linkers 関連製品 (4095)
関連製品 (4095)
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PROTAC Linkers Isoform Comparison
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DBCO-PEG4-DBCO
0 Images製品番号: HY-130346CAS 番号: 2182601-68-7DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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Azido-PEG16-NHS ester
0 ImagesAzido-PEG16-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG16-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG1-C2-acid
0 ImagesAzido-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Tetraethylene glycol (テトラエチレングリコール)
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N-Boc-serinol
0 Images製品番号: HY-W018464CAS 番号: 125414-41-7
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tert-Butyl (10-aminodecyl)carbamate
0 Images製品番号: HY-W047688CAS 番号: 216961-61-4別名: 1-Boc-1,10-diaminodecanetert-Butyl (10-aminodecyl) carbamate (1-Boc-1,10-diaminodecane) is a synthetic intermediate that serves as a PROTAC linker in PROTAC synthesis and other conjugation applications. tert-Butyl (10-aminodecyl) carbamate is an alkane chain with a terminal amine and a Boc-protected amino group. The amine group can react with carboxylic acids, active NHS esters, carbonyl groups (ketones, aldehydes), etc. The Boc group can be deprotected under mild acidic conditions to form a free amine.
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exo-BCN-L-Lysine
0 Images製品番号: HY-W754588CAS 番号: 1384100-45-1exo-BCN-L-Lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. exo-BCN-L-Lysine contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
![tert-Butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate](https://file.medchemexpress.com/product_pic/hy-w007836.gif "Click to View tert-Butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Product Detail")
![2-[4-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-1-yl]acetic acid](https://file.medchemexpress.com/product_pic/hy-w158606.gif "Click to View 2-[4-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-1-yl]acetic acid Product Detail")
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14-Bromotetradecan-1-ol
0 Images製品番号: HY-W033978CAS 番号: 72995-94-9
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Azido-PEG6-NHS ester
0 ImagesAzido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Mal-PEG12-NHS ester
0 Images製品番号: HY-140963CAS 番号: 2669737-09-9
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L-Homopropargylglycine hydrochloride
0 ImagesL-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor.
